{"id":1544,"date":"2014-10-25T02:37:08","date_gmt":"2014-10-25T02:37:08","guid":{"rendered":"http:\/\/ixyzero.com\/blog\/?p=1544"},"modified":"2014-10-25T02:37:08","modified_gmt":"2014-10-25T02:37:08","slug":"collect%e5%a6%82%e4%bd%95%e5%bf%ab%e9%80%9f%e7%a0%94%e7%a9%b6%e9%80%8f%e4%b8%80%e7%af%87paper%e5%b9%b6%e6%8f%90%e5%87%ba%e6%9c%89%e4%bb%b7%e5%80%bc%e7%9a%84%e9%97%ae%e9%a2%98%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/ixyzero.com\/blog\/archives\/1544.html","title":{"rendered":"[collect]\u5982\u4f55\u5feb\u901f\u7814\u7a76\u900f\u4e00\u7bc7paper\u5e76\u63d0\u51fa\u6709\u4ef7\u503c\u7684\u95ee\u9898\uff1f"},"content":{"rendered":"
\u5982\u4f55\u5feb\u901f\u7814\u7a76\u900f\u4e00\u7bc7paper\u5e76\u63d0\u51fa\u6709\u4ef7\u503c\u7684\u95ee\u9898\uff1f<\/h5>\n

@\u6b27\u9633\u7b20
\n\u7b54\u6848\u5f88\u7b80\u5355\uff0c\u5305\u62ec\u4e24\u70b9\u3002\u7b2c\u4e00\uff0c\u6bd4\u8f83\u9605\u8bfb\u540c\u9886\u57df10\u7bc7\u4ee5\u4e0a\u6587\u7ae0<\/span>\u3002\u7b2c\u4e8c\uff0c\u753b\u601d\u7ef4\u5bfc\u56fe\u3002<\/strong><\/p>\n

\u5148\u8bf4\u7b2c\u4e00\u70b9\uff0c\u539f\u56e0\u6709\u4e8c\u3002<\/p>\n

1. \u5de7\u5987\u96be\u4e3a\u65e0\u7c73\u4e4b\u708a<\/strong><\/span>
\n\u73b0\u5728\u5b66\u672f\u754c\u7684\u7ec6\u5206\u5df2\u7ecf\u8fbe\u5230\u4e86\u4e00\u4e2a\u5f88\u9ad8\u7684\u7a0b\u5ea6\uff0c\u79d1\u7814\u4e0a\u7684\u5168\u624d\u8d8a\u6765\u8d8a\u5c11\uff0c\u7edd\u5927\u591a\u6570\u662f\u5728\u67d0\u4e2a\u9886\u57df\u6df1\u5ea6\u6316\u6398\u7684\u5927\u62ff\u3002\u5373\u4f7f\u662f\u8bfa\u5956\u5f97\u4e3b\uff0c\u62ff\u5230\u4e0d\u719f\u6089\u9886\u57df\u7684\u5355\u4e00\u67d0\u7bc7\u6587\u7ae0\uff0c\u8981\u770b\u51fa\u4e2a\u95e8\u9053\u6765\u4e5f\u4e0d\u662f\u4e00\u4ef6\u5bb9\u6613\u7684\u4e8b\u60c5\u3002\u4efb\u4f55\u4e00\u7bc7\u5b66\u672f\u8bba\u6587\u90fd\u662f\u5efa\u7acb\u5728\u5927\u91cf\u76f8\u5173\u7814\u7a76\u7684\u57fa\u7840\u4e0a\uff0c\u6ca1\u6709\u5bf9\u76f8\u5173\u80cc\u666f\u77e5\u8bc6\u7684\u79ef\u7d2f\uff0c\u6307\u671b\u81ea\u5df1\u7075\u5149\u4e00\u95ea\u662f\u4e0d\u5927\u73b0\u5b9e\u7684\u3002\u8bc1\u636e\u5c31\u662f\u6295\u7a3f\u5927\u591a\u6570\u6742\u5fd7\u65f6\uff0c\u7f16\u8f91\u90fd\u4f1a\u627e\u76f8\u5173\u9886\u57df\u7684\u4e13\u5bb6\u6765\u5ba1\u7a3f\u3002\u56e0\u4e3a\uff0c\u5f88\u591a\u4e1c\u897f\u53ea\u6709\u5185\u884c\u624d\u770b\u5f97\u51fa\u6765\u3002<\/p>\n

2. \u662f\u9aa1\u5b50\u662f\u9a6c\uff0c\u7275\u51fa\u6765\u905b\u905b<\/span><\/strong>
\n\u540c\u4e00\u4e2a\u79d1\u5b66\u95ee\u9898\uff0c\u53ef\u80fd\u4e0d\u540c\u5b9e\u9a8c\u5ba4\u7684\u7814\u7a76\u8005\u7528\u4e0d\u540c\u7684\u65b9\u6cd5\u5f97\u5230\u76f8\u4f3c\u6216\u8005\u76f8\u53cd\u7684\u7ed3\u8bba\u3002\u901a\u8fc7\u5168\u9762\u6bd4\u8f83\u4e0d\u540c\u7814\u7a76\u8005\u7684\u6587\u7ae0\uff0c\u66f4\u5bb9\u6613\u5f97\u51fa\u4e00\u4e9b\u6709\u4ef7\u503c\u7684\u60f3\u6cd5\u3002\u4e3e\u4e2a\u7b80\u5355\u7684\u7b20\u5b50\u5427\u3002<\/p>\n

\u5e74\u521d\u5c0f\u4fdd\u65b9\u6674\u5b50\u53d1\u8868\u4e86\u4e00\u7bc7Nature\u6587\u7ae0\uff08Stimulus-triggered fate conversion of somatic cells into pluripotency : Nature : Nature Publishing Group<\/a>\uff09\uff0c\u5982\u4f60\u6240\u77e5\uff0c\u5979\u7528\u7b80\u5355\u7684\u6539\u53d8\u57f9\u517b\u57fapH\u7684\u65b9\u6cd5\u5236\u9020\u51fa\u4e86induced pluripotent stem cells (iPSCs)\u3002\u522b\u8bf4\u4f5c\u4e3a\u4e00\u4e2a\u95e8\u5916\u6c49\uff0c\u5f53\u65f6\u6211\u8eab\u8fb9\u7684\u4e0d\u5c11PhD\u770b\u4e86\u6587\u7ae0\u90fd\u5728\u5567\u5567\u79f0\u5947\uff0c\u8ba8\u8bba\u5982\u679c\u65e9\u70b9\u53d1\u8868\uff0c\u8bfa\u8d1d\u5c14\u5956\u8bf4\u4e0d\u5b9a\u5c31\u8981\u6613\u4e3b\u4e86\u3002<\/p>\n

\u5176\u5b9e\u53ea\u8981\u6bd4\u8f83\u9605\u8bfb\u5c0f\u4fdd\u65b9\u6674\u5b50\u7684\u6587\u7ae0\u548c\u8bfa\u5956\u5f97\u4e3b\u5c71\u4e2d\u4f38\u5f2506\u7684\u6587\u7ae0\uff08Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors: Cell<\/a>\uff09\u5c31\u4e0d\u96be\u53d1\u73b0\uff0c\u5c71\u4e2d\u4f38\u5f25\u8d39\u4e86\u4e5d\u725b\u4e8c\u864e\u4e4b\u529b\uff0c\u75284\u4e2a\u8f6c\u5f55\u56e0\u5b50\u901a\u8fc7\u75c5\u6bd2\u8f7d\u4f53\u624d\u4ee5\u6781\u4f4e\u7684\u6548\u7387\u4ea7\u751f\u4e86ips\u3002\u968f\u540e\u51e0\u5e74\uff0c\u5404\u5927\u5b9e\u9a8c\u5ba4\u4e5f\u90fd\u82e6\u5fc3\u5b64\u8be3\u63d0\u9ad8ips\u8bf1\u5bfc\u6548\u7387\u3002\u6bd4\u8f83\u4e24\u7bc7\u6587\u7ae0\u4e5f\u80fd\u53d1\u73b0\uff0c\u5c71\u4e2d\u4f38\u5f25\u7684\u6587\u7ae0\u8bc1\u636e\u5145\u5206\uff0c\u5404\u9879\u6570\u636e\uff0c\u8bc1\u636e\u94fe\u9f50\u5168\uff0c\u5b9e\u5728\u662f\u5f88\u624e\u5b9e\u7684\u4e00\u7bc7\u6587\u7ae0\uff08Cell\u7684\u4e00\u8d2f\u98ce\u683c\uff09\u3002\u53cd\u89c2\u5c0f\u4fdd\u65b9\u6674\u5b50\uff0c\u5979\u8c08\u7b11\u95f4\u6a2f\u6a79\u7070\u98de\u706d\uff0c\u76f4\u63a5\u653e\u70b9\u918b\u5c31\u884c\u4e86\uff0c\u542c\u4e0a\u53bb\u5c31\u50cf\u6c34\u53d8\u6c7d\u6cb9\u7684\u795e\u8bdd\u3002\u679c\u4e0d\u5176\u7136\uff0c\u6570\u6708\u540e\uff0c\u6ce1\u6cab\u5c31\u88ab\u6233\u7834\u4e86\u3002\u6240\u4ee5\uff0c\u6bd4\u8f83\u9605\u8bfb\u5b9e\u5728\u662f\u4e00\u628a\u5229\u5668\u3002
\n\u7b2c\u4e8c\u70b9\u5c31\u662f\u63d0\u7eb2\u6308\u9886\uff0c\u753b\u601d\u7ef4\u5bfc\u56fe\u3002
\n\u7b2c\u4e00\u6b65\uff0c\u5148\u770b\u6587\u7ae0abstract\uff0c\u5bf9\u6587\u7ae0\u7684\u4e3b\u9898\u6709\u4e2a\u5927\u6982\u5370\u8c61\u3002<\/p>\n

\u7b2c\u4e8c\u6b65\uff0c\u76f4\u63a5\u53bb\u770bResults\u90e8\u5206\u7684\u5c0f\u6807\u9898\u3002\u8fd9\u662f\u6587\u7ae0\u7684\u8109\u7edc\uff0c\u628a\u8fd9\u4e9b\u6807\u9898\u4e32\u8d77\u6765\u5c31\u7ec4\u6210\u4e86\u6587\u7ae0\u7684\u6545\u4e8b\u4e3b\u4f53\u3002\u5206\u6790\u5176\u903b\u8f91\u7ed3\u6784\uff0c\u770b\u80fd\u4e0d\u80fd\u81ea\u5706\u5176\u8bf4\uff0c\u4ee5\u53ca\u8bc1\u636e\u94fe\u5b8c\u6574\u4e0e\u5426\u3002\u53ef\u4ee5\u4f7f\u7528GRE argument\u5199\u4f5c\u4e2d\u7684\u601d\u8fa8\u65b9\u6cd5\u3002<\/p>\n

\u7b2c\u4e09\u6b65\uff0c\u6df1\u5165Results\u7684\u5404\u4e2a\u90e8\u5206\uff0c\u7b80\u5355\u6765\u8bf4\uff0c\u5c31\u662f\u770b\u63d0\u4f9b\u7684\u6570\u636e\u80fd\u4e0d\u80fd\u652f\u6301\u6bcf\u4e2a\u90e8\u5206\u7684\u603b\u7ed3\u53e5\u5b50\uff08\u5f80\u5f80\u5728\u6bb5\u843d\u672b\u5c3e\uff09\u3002<\/p>\n

\u7b2c\u56db\u6b65\uff0c\u7814\u7a76Discussion\u90e8\u5206\uff0c\u8fd9\u662f\u6587\u7ae0\u7684\u7cbe\u534e\u6240\u5728\u3002\u6700\u8fd1\u770b\u5230\u7684\u4e00\u7bc7discussion\u5199\u5f97\u5f88\u597d\u7684\u6587\u7ae0\uff0c\u5927\u5bb6\u53ef\u4ee5\u501f\u9274\u4e00\u4e0b\uff08http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17015822<\/a>\uff09\u3002\u6587\u7ae0\u6709\u70b9\u8001\uff0c\u5927\u5bb6\u522b\u4ecb\u610f~<\/p>\n

==========================================================
\n\u603b\u7ed3\u4e0b\uff0c\u8981\u8bfb\u900f\u6587\u7ae0\u5e76\u63d0\u51fa\u6709\u4ef7\u503c\u7684\u95ee\u9898\uff0c\u8bfb\u4e00\u7bc7\u6587\u7ae0\u80af\u5b9a\u662f\u4e0d\u591f\u7684\u3002\u90a3\u4e48\u95ee\u9898\u6765\u4e86\uff0c\u5982\u4f55\u627e\u5230\u76f8\u5173\u6587\u7ae0\u5462\uff1f\u6700\u7b80\u5355\u7684\u65b9\u6cd5\u662f\u770b\u6587\u7ae0\u7684References\uff0c\u628a\u5176\u5f15\u7528\u7684\u76f8\u5173\u6587\u732e\u770b\u4e00\u770b\u3002\u6700\u540e\u8fd8\u6709\u4e2a\u9ad8\u9636\u7248\u65b9\u6cd5\u3002<\/p>\n

\"Google<\/a><\/p>\n

\u5f53\u641c\u7d22\u4e00\u7bc7\u6587\u7ae0\u540e\uff0c\u5728\u7bad\u5934\u6240\u793a\u4f4d\u7f6e\u4f1a\u663e\u793a\u88ab\u5f15\u7528\u6b21\u6570\uff0c\u70b9\u8fdb\u53bb\uff0c\u5c31\u53ef\u4ee5\u770b\u89c1\u5f15\u7528\u8fc7\u8fd9\u7bc7\u6587\u7ae0\u7684\u76f8\u5173\u6587\u7ae0\u4e86\u3002\u800c\u4e14\u8fd9\u4e9b\u6587\u7ae0\u6bd4\u8be5\u6587\u7ae0\u7684References\u65b0\u3002\u5728\u79d1\u5b66\u754c\uff0c\u65f6\u6548\u6027\u662f\u5f88\u91cd\u8981\u7684\u3002\u6240\u4ee5\u770b\u8d8a\u65b0\u7684\u6587\u7ae0\u4e00\u822c\u4e5f\u4f1a\u8d8a\u597d\u3002
\n======================<\/p>\n

@\u72d0\u72f8\u5148\u751f
\n\u6211\u4e2a\u4eba\u7684\u611f\u89c9\u662f\u8981\u9760\u79ef\u7d2f\uff0c\u6240\u8c13\u529f\u592b\u5728\u8bd7\u5916<\/strong><\/span>\u3002
\n\u79d1\u6280\u8bba\u6587\u81ea\u8eab\u6709\u6bd4\u8f83\u6e05\u6670\u7684\u903b\u8f91\u7ed3\u6784\u3002
\n\u6458\u8981\u4f1a\u6982\u8ff0\u8bba\u6587\u7684\u5185\u5bb9\u548c\u6700\u91cd\u8981\u7684\u7ed3\u679c\u3002
\n\u4ecb\u7ecd\u90e8\u5206\u4f1a\u9610\u8ff0\u8bba\u6587\u76f8\u5173\u9886\u57df\u7684\u7814\u7a76\u8109\u7edc\u548c\u672c\u8bfe\u9898\u7684\u76ee\u7684\uff0c\u610f\u4e49\u3002
\n\u65b9\u6cd5\u90e8\u5206\u4f1a\u4ecb\u7ecd\u672c\u8bba\u6587\u7684\u5b9e\u65bd\u65b9\u6cd5\uff0c\u6280\u672f\uff0c\u8ba1\u7b97\u516c\u5f0f\u7b49\u7b49\u3002
\n\u7ed3\u679c\u90e8\u5206\u4f1a\u6709\u4e00\u4e24\u526f\u56fe\u5c55\u793a\u6700\u91cd\u8981\u7684\u7ed3\u679c\uff0c\u8fd8\u4f1a\u6709\u82e5\u5e72\u652f\u6491\u56fe\u8868\uff0c\u8bf4\u660e\u7ed3\u679c\u7684\u53ef\u9760\u6027\u3002
\n\u6700\u540e\u7ed3\u8bba\u90e8\u5206\u4f1a\u6309\u9879\u5217\u4e3e\u672c\u6587\u505a\u8fc7\u7684\u4e8b\u60c5\uff0c\u5f97\u51fa\u7684\u7ed3\u679c\u3002<\/p>\n

\u6240\u4ee5\u5982\u679c\u9605\u8bfb\u65e0\u788d\uff0c\u79d1\u6280\u8bba\u6587\u5f88\u5bb9\u6613\u7406\u89e3\u3002
\n\u4f46\u662f\uff0c\u5f88\u591a\u95ee\u9898\u5e76\u4e0d\u80fd\u9760\u8bba\u6587\u81ea\u8eab\u89e3\u91ca\uff0c\u4f8b\u5982\uff1a
\n\u8bba\u6587\u7684\u4ef7\u503c\u7a76\u7adf\u5982\u4f55\uff0c\u8fd9\u4e0d\u5149\u8981\u770b\u4ecb\u7ecd\u90e8\u5206\u4f5c\u8005\u81ea\u5df1\u7684\u7efc\u8ff0\uff0c\u56e0\u4e3a\u4f5c\u8005\u5f80\u5f80\u503e\u5411\u4e8e\u5938\u5927\u81ea\u5df1\u7814\u7a76\u7684\u610f\u4e49\uff0c\u56e0\u6b64\u8fd8\u9700\u8981\u4f60\u5bf9\u76f8\u5173\u9886\u57df\u7814\u7a76\u60c5\u51b5\u6709\u4e00\u5b9a\u7684\u628a\u63e1\u3002
\n\u518d\u6bd4\u5982\uff0c\u8bba\u6587\u7684\u7ed3\u679c\u662f\u5426\u5408\u7406\uff0c\u53ef\u4fe1\u3002\u8fd9\u5c31\u9700\u8981\u4f60\u5bf9\u8be5\u8bba\u6587\u4f7f\u7528\u7684\u65b9\u6cd5\uff0c\u7406\u8bba\u7684\u6846\u67b6\u6709\u6bd4\u8f83\u6df1\u523b\u7684\u7406\u89e3\u3002
\n\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\uff0c\u9664\u4e86\u591a\u8bfb\uff0c\u591a\u5b66\u4e60\uff0c\u6ca1\u6709\u592a\u591a\u522b\u7684\u65b9\u6cd5\u3002<\/span>
\n======================<\/p>\n

@zheye zhihu
\n\u8ddf\u7740\u81ea\u5df1\u7684\u601d\u8def\u8d70\u3002\u770b\u770b\u4f5c\u8005\u6709\u6ca1\u6709\u56de\u7b54\u597d\u56db\u4e2a\u95ee\u9898\uff1a<\/p>\n

\u7b2c\u4e00\uff0c\u79d1\u5b66\u95ee\u9898\u662f\u4ec0\u4e48\uff1f
\n\u7b2c\u4e8c\uff0c\u7528\u4ec0\u4e48\u65b9\u6cd5\u89e3\u51b3\u7684<\/span>\uff1f
\n\u7b2c\u4e09\uff0c\u4e3a\u4ec0\u4e48\u7528\u8fd9\u4e2a\u65b9\u6cd5<\/strong><\/span>\uff1f
\n\u7b2c\u56db\uff0c\u5f97\u5230\u4e86\u600e\u4e48\u6837\u7684\u7ed3\u679c\uff1f<\/p>\n

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